Caffeic Acid Inhibits Tumour Mass Formation in MG-63 Cells-induced Nude Mice

BACKGROUND: Formation of tumour mass is one symptom osteosarcoma development. Caffeic acid has been known to provide effective treatment but less side effect for some cancer therapy. Studies reported that caffeic might promote apoptosis in MG-63 cells, however, the preventing formation not well elucidated, especially cells-induced nude mice vivo.METHODS: cells were pre-treated with 0, 1, or 10 µg/mL acid, and 6 hours after pre-treatment, injected into subcutaneous space induce osteosarcoma. Another model was also created by subcutaneously injecting back mice, 48 days, visible intra-tumour 0 every 7 days times. After 90 anaesthetised, nodule pictures taken observation measurement. RESULTS: In volumes decreased reverse dose given. Ten pre-treatment able significantly lower volume compared untreated (p<0.05). Meanwhile, even though significant, inhibit formation.CONCLUSION: Results show formation. This suggests can be a potential anti-cancer agent.KEYWORDS: osteosarcoma,